CBDV vs CBD: Get to Know their Differences and Similarities

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Researchers have identified more than 100 cannabinoids in the marijuana or hemp plant. The most common ones are CBD and THC, which has been used to treat certain diseases and health conditions. THC has a homolog known as
THCV, also dubbed as the “weight loss cannabinoid” while CBD has CBDV, known to treat symptoms of seizures.

In case you haven’t heard about CBDV yet, we’re about to tell you about this emerging cannabinoid, while highlighting its differences and similarities with

An Overview on CBD

CBD stands for cannabidiol, the second most prevalent of the active ingredients of cannabis (marijuana). While CBD is an essential component of medical marijuana, it is derived directly from the hemp plant, which is a cousin of the marijuana plant.

Although CBD is a component of marijuana, it does not cause psychoactive effects or the “high” feeling. According to World Health Organization, “In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health related problems associated with the use of pure CBD.”

What Is CBDV?

CBDV is short for cannabidivarin, a cannabinoid closely related with CBD in terms of chemical structure (as shown below). There is a slight difference at the propyl chain that CBDV carries. CBDV can be used to develop THCV (tetrahydrocannabivarin) when it’s exposed to an acidic environment, and CBD doesn’t have this same ability to transform into THC.

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What is CBDV

How Do Cannabinoids like CBD and CBDV Work?

Cannabinoids interact with the body through the endocannabinoid system (ECS), an active and complex cell signaling network. The ECS involves a combination of endocannabinoids, enzymes, and cannabinoid receptors that help regulate several functions in the human body.

Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system, which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory. There are currently two known subtypes of cannabinoid receptors, namely CB1 and CB2.

The CB1 receptor is expressed mainly in the brain or central nervous system (CNS), but also in the lungs, liver and kidneys. The CB2 receptor is expressed mainly in the immune system and in hematopoietic cells, the stem cells that give rise to other blood cells found in the bone marrow.

CBDV VS CBD: What Is The Difference Between CBDV and CBD?

While CBDV is closely related to CBD in terms of molecular structure, they both posses different effects and benefits to the body due to the way they interact with the cannabinoid receptors.

CBD has a low binding affinity for CB1 and CB2 receptors, modulating the psychoactive effects. Beyond the endocannabinoid receptors, CBD activates other receptors and ion channels that have a plethora of positive effects. For example, CBD can activate a serotonin receptor that helps alleviate symptoms such as anxiety, nausea, vomiting, and the perception of pain.

Research suggests that CBDV, known for its anticonvulsant actions, works using a different mechanism from THC, CBD, and other cannabinoids. While THC and CBD produce their effects by interacting with the CB1 and CB2 receptors in the body, the anti-epileptic activity of CBDV is modulated by activating the capsaicin receptor. CBDV desensitizes this ion channel causing a reduction in neuronal hyperexcitability, and this helps to minimize convulsant activity and associated seizures in the body.

Comparing the Benefits of CBDV Vs CBD

Although there is not much research on CBDV, the little that currently exists looks promising. Scientists claim that CBDV has several similarities with its cousin cannabinoid,

The notable similarities between CBDV and CBD are their molecular structure and the non-psychoactive properties.

Most of the research based on cannabinoids has centered around CBD as a primary focus, claiming some of the following benefits of this non-intoxicating cannabinoid:

  • Inflammation
  • nausea management
  • seizure reduction
  • anxiety management
  • depression management
  • pain relief
  • sedation

All cannabinoids have their own unique identity. Research on CBDV is still limited, however, studies claim it has the following potential benefits:

  • Seizures
  • Rett Syndrome
  • Reduce Inflammation and Enhance Muscle Function
  • Anti-Nausea Agent

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CBDV Benefits

CBDV vs CBD: In Summary

Both CBD and CBDV are non-psychoactive cannabinoids found in both hemp and marijuana plants. They are closely related in terms of chemical structure, with a slight difference in their propyl chain. These cannabinoids both offer medical benefits and this area is where they differ due to their interaction with the cannabinoid receptors.

Several studies claim that CBD offer therapeutic effects such reducing inflammation, pain relief, anxiety, and sedation to name a few. On the other hand, researching concerning about CBDV is still at its infancy stage, but it offers therapeutic potential as well.

To date, CBDV is known to have anticonvulsant properties or the ability to suppress the excessive rapid firing of neurons during seizures, preventing the spread within the brain.

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